Professor
Wei-Ping Liao

Luo S^#, Wang PY^#, Zhou P^#, Zhang WJ, Gu YJ, Liang XY, Zhang JW, Luo JX, Zhang HW, Lan S, Zhang TT, Yang JH, Sun SZ, Guo XY, Wang JL, Deng LF, Xu ZH, Jin L, He YY, Ye ZL, Gu WY, Li BM, Shi YW, Liu XR, Yan HJ, Yi YH, Jiang YW, Mao X, Li WL, Meng H^*, Liao WP^*. Variants in EP400, encoding a chromatin remodeler, cause epilepsy with neurodevelopmental disorders. Am J Hum Genet. 2025 Jan 2;112(1):87-105. doi: 10.1016/j.ajhg.2024.11.010. Epub 2024 Dec 20. PMID: 39708813.

Wang J^#, Qiao JD^#, Liu XR, Liu DT, Chen YH, Wu Y, Sun Y, Yu J, Ren RN, Mei Z, Liu YX, Shi YW, Jiang M, Lin SM, He N, Li B, Bian WJ, Li BM, Yi YH, Su T, Liu HK, Gu WY, Liao WP^*. UNC13B variants associated with partial epilepsy with favourable outcome. Brain. 2021;144(10):3050-3060. PMID: 33876820.

Qiao JD, Li X, Li J, Guo QH, Tang XQ, Chen LZ, Su T, Yi YH, Wang J, Liao WP^*. Reply: UNC13B and focal epilepsy. Brain. 2022 Apr 29;145(3):e13-e16. doi: 10.1093/brain/awab486. PMID: 35380625.

Shi YW^#, Zhang Q^#, Cai K^#, Poliquin S, Shen W, Winters N, Yi YH, Wang J, Hu N, Macdonald RL, Liao WP^*, Kang JQ^*. Synaptic clustering differences due to different GABRB3 mutations cause variable epilepsy syndromes. Brain. 2019 Oct 1;142(10):3028-3044; PMCID: PMC6776116. PMID: 31435640.

Fan CX^#, Liu XR^#, Mei DQ^#, Li BM, Li WB, Xie HC, Wang J, Shen NX, Ye ZL, You QL, Li LY, Qu XC, Chen LZ, Liang JJ, Zhang MR, He N, Li J, Gao JY, Deng WY, Liu WZ, Wang WT, Liao WP, Chen Q^*, Shi YW^*. Heterozygous variants in USP25 cause genetic generalized epilepsy. Brain. 2024 Oct 3;147(10):3442-3457. doi: 10.1093/brain/awae191. PMID: 38875478.

Ye ZL^#, Li WB^#, Fan CX^#, Wang J, Li B, Luo S, Lin ZS, Gao LD, Su T, Yi YH, Shi YW^*, Liao WP^*. Reply: USP25 in genetic generalized epilepsy: a gene under scrutiny. Brain. 2026 Feb 7;149(2):e19-e22. doi: 10.1093/brain/awaf407. PMID: 41144627.

Luo S^#, Wang PY^#, Liu WH^#, Liang XY, Gu YJ, Ye YC, Zhou P, Yi YH, Meng H^*, Liao WP^*. Age at onset of genetic disease and genetic dependent stage: evidence from cases with SCN1A variants. Brain. 2025 Jul 7;148(7):e56-e60. doi: 10.1093/brain/awaf064. PMID: 39969241.

Shi YW^#, Zhang JG^#, Ye ZL^#, He N, Li WB, Liu HK, Liu ZG, Shen NX, Qu XC, Fan CX, Wang J, Luo S, Lv YD, Gao L, Chen J, Huang SP, Lu XG, Yu J, Zhang J, Wang XX, Gao QW, Jiang L, Chen YH, Qi H, Qiao JD, Chen LZ, Zeng YJ, Yang XX, Yan HJ, Li CY, Zeng T, Min FL, Qin B, Xu HQ, Xu L, Li BM, Yi YH, Zhuo ZH, Guo QH, He SL, Zhang HW, Guan LP, Deng WY, Ren XF, Zou DF, Gu WY, Su T, Liu XR, Qu YB, Yang XP, Liao WP^*. Identification of novel potential causative genes of childhood epileptic encephalopathies. Genes & Diseases. 2026;102199. Published online 20 April 2026. doi: 10.1016/j.gendis.2026.102199.

Bayat A^#*, Liu Z^#, Luo S^#, Fenger CD, Højte AF, Isidor B, Cogne B, Larson A, Zanus C, Faletra F, Keren B, Musante L, Gourfinkel-An I, Perrine C, Demily C, Lesca G, Liao W^*, Ren D. A new neurodevelopmental disorder linked to heterozygous variants in UNC79. Genet Med. 2023 Sep;25(9):100894. doi: 10.1016/j.gim.2023.100894. Epub 2023 May 11. PMID: 37183800.

Liang XY^#, Meng XH^#, Wu WC^#, Guo J, Luo S, Wang PY, Zhang DM, Lin ZS, Liang JJ, He SL, Li BM, Wang J, Yi YH, He N^*, Liao WP^*; China Epilepsy Gene 1.0 Project. De novo SRCAP variants cause developmental and epileptic encephalopathy and the phenotypic spectrum. Epilepsia. 2026 Feb;67(2):846-861. doi: 10.1111/epi.18695. Epub 2025 Oct 27. PMID: 41144712.

Li X^#, Wang L^#, Liang XY, Zhang HW, Shi JG, Guo J, Zou DF, Chen J, He SL, Xie YP, Peng Q, Zhu JP, He N, Deng WW, Luo S, Wang PY, Zhang DM, Zhu JH, Li BM, Geng GF, Gao ZF, Wang J^*, Liao WP^*; China Epilepsy Gene 1.0 Project. Variants in CSMD2 and CSMD3, genes involved in synaptogenesis, are associated with epilepsies. Epilepsia. 2025 Nov;66(11):4394-4410. doi: 10.1111/epi.18539. Epub 2025 Jul 9. PMID: 40632521.

Luo S^#, Zhang WJ^#, Jiang M^#, Ren RN, Liu L, Li YL, Liu WH, Wang PY, Gu YJ, Chen LZ, Shen LP, Tian Y, Liu XR, Yi YH, Liao WP^*, Zhou P^*; China Epilepsy Gene 1.0 Project. De novo TANC2 variants caused developmental and epileptic encephalopathy and epilepsy. Epilepsia. 2025 Jul;66(7):2365-2378. doi: 10.1111/epi.18358. Epub 2025 Mar 20. PMID: 40110879.

Liu CQ^#, Sun MZ^#, Lin YM, Zhang XX, Huang RN, He MF, Luo S, Luo SY, Huang T, Jiang N, Luo J, Zhang JX, Chen PR, Dai X, Han TA, Liao WP^*, Peng RC^*, Qiao JD^*. Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A-CELSR2 digenic mutations. Epilepsia. 2025 Jul;66(7):2391-2406. doi: 10.1111/epi.18390. Epub 2025 Apr 4. PMID: 40184228.

He N^#, Lin ZJ^#, Wang J, Wei F, Meng H, Liu XR, Chen Q, Su T, Shi YW, Yi YH, Liao WP^*. Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies. Genet Med. 2019 Jan;21(1):17-27. Epub 2018 Jun 12; PMCID: PMC6752304. PMID: 29895856.

Tang B^#, Li B^#, Gao LD, He N, Liu XR, Long YS, Zeng Y, Yi YH, Su T, Liao WP^*. Optimization of in silico tools for predicting genetic variants: individualizing for genes with molecular sub-regional stratification. Brief Bioinform. 2020 Sep 25;21(5):1776-1786. PMID: 31686106.

Meng H, Xu HQ, Yu L, Lin GW, He N, Su T, Shi YW, Li B, Wang J, Liu XR, Tang B, Long YS, Yi YH, Liao WP^*. The SCN1A mutation database: updating information and analysis of the relationships among genotype, functional alteration, and phenotype. Hum Mutat. 2015 Jun;36(6):573-80. PMID: 25754450.

Shi YW^#, Min FL^#, Zhou D, Qin B, Wang J, Hu FY, Cheung YK, Zhou JH, Hu XS, Zhou JQ, Zhou LM, Zheng ZZ, Pan J, He N, Liu ZS, Hou YQ, Lim KS, Ou YM, Hui-Ping Khor A, Ng CC, Mao BJ, Liu XR, Li BM, Kuan YY, Yi YH, He XL, Deng XY, Su T, Kwan P^*, Liao WP^*. HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions. Neurology. 2017 Jun 6;88(23):2183-2191. Epub 2017 May 5; PMCID: PMC5467955. PMID: 28476759.

He N^#, Guan BZ^#, Wang J, Liu HK, Mao Y, Liu ZG, Yin F, Peng J, Xiao B, Tang BS, Zhou D, Huang G, Dai QL, Zeng Y, Han H, Zhai QX, Li B, Tang B, Li WB, Song W, Liu L, Shi YW, Li BM, Su T, Zhou P, Liu XR, Guo LW, Yi YH, Liao WP^*. HCFC1 variants in the proteolysis domain are associated with X-linked idiopathic partial epilepsy: Exploring the underlying mechanism. Clin Transl Med. 2023 Jun;13(6):e1289. doi: 10.1002/ctm2.1289. PMID: 37264743.

Li J^#, Lin SM^#, Qiao JD, Liu XR, Wang J, Jiang M, Zhang J, Zhong M, Chen XQ, Zhu J, He N, Su T, Shi YW, Yi YH, Liao WP^*; China Epilepsy Gene 1.0 Project. CELSR3 variants are associated with febrile seizures and epilepsy with antecedent febrile seizures. CNS Neurosci Ther. 2022 Mar;28(3):382-389. doi: 10.1111/cns.13781. Epub 2021 Dec 23. PMID: 34951123.

Zhang MW^#, Liang XY^#, Wang J^#, Gao LD, Liao HJ, He YH, Yi YH, He N^*, Liao WP^*; China Epilepsy Gene 1.0 Project. Epilepsy-associated genes: an update. Seizure. 2024 Mar;116:4-13. doi: 10.1016/j.seizure.2023.09.021. Epub 2023 Sep 23. PMID: 37777370.

Liao WP^*. Epilepsy-associated genes: discovery, clinical significance, and underlying principles of genetic medicine. Seizure. 2024 Mar;116:1-3. doi: 10.1016/j.seizure.2024.01.002. Epub 2024 Jan 3. PMID: 38245481.

He N^#, Li B^#, Lin ZJ, Zhou P, Su T, Liao WP^*. Common genetic epilepsies, pathogenicity of genes/variants, and genetic dependence. Seizure. 2023 Jul;109:38-39. doi: 10.1016/j.seizure.2023.05.008. Epub 2023 May 11. PMID: 37207537.

Guerrini R, Marsh ED, Liao WP, Imai K, Kravljanac R, Altmann A, Hahn CD, Auvin S, Schiemann J, Khan Y, Mitra P, Sheikh SI, von Rosenstiel P, Asgharnejad M, Dlugos D, Murthy V^*. A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox-Gastaut syndrome. Epilepsia. 2026 Jul;67(7):3420-3431. doi: 10.1002/epi.70216. Epub 2026 Mar 27. PMID: 41891667.

Ye Z^#, Li B^#, Xie L^#, Fei L, Lu X, He Y, Wang J, Chen Y, Liao W, Shi Y^*. Variants in ARHGAP21, encoding a Rho GTPase-activating protein, are associated with focal epilepsy and neurodevelopmental disorders. Genes Dis. 2025 Dec 15;13(5):101988. doi: 10.1016/j.gendis.2025.101988. eCollection 2026 Sep. PMID: 42028452.

Yu P^#, Wu X^#, Cui L, Pan S, Han Y, Xu H, Zhu S, Wang X, Huang H, Wang T, Liao W, Zhang M, Tang L, Sun H, Qin B, Hu Z, Feng J, Chen Y, Zhang M, Li Q, Han X, Xiao B, Chen H, Li L, Liang Y, Ye H, Liu Y, Hong Z^*, Zhou D^*. Efficacy and Safety of Adjunctive Cenobamate in Chinese Participants with Focal Seizure. Adv Ther. 2026 Feb;43(2):688-709. doi: 10.1007/s12325-025-03432-z. Epub 2025 Dec 22. PMID: 41428177.

Li YF^#, Mo P^#, Zhang LZ^#, Zhou XL, Zhu WY, Zhu JH, Liao SH, Chen YT, Deng W, Zhang DM, Liu XR, Chen YJ, Liao WP, Wang J, Cheng CF^*; China Epilepsy Gene 1.0 Project. CACNA1C variants associated with focal epilepsy and their correlations with arrhythmias and developmental disorders. J Med Genet. 2026 Aug 6:jmg-2025-110918. doi: 10.1136/jmg-2025-110918. Online ahead of print. PMID: 42562628.

Zhang KL^#, Wang J^#, Tang ZH, Zhai QX, Peng YY, Li BM, Liu XR, Peng Q^*, Li B^*, Liao WP. Epilepsy in NHS actin remodeling regulator gene (NHS) and genotype-phenotype correlations. Pediatr Res. 2026 Feb;99(3):1096-1103. doi: 10.1038/s41390-025-04335-z. Epub 2025 Aug 15. PMID: 40817290.

Zhang W^#, Luo S^#, Jiang M^#, Chen Y, Ren R, Wu Y, Wang P, Zhou P, Qin J^*, Liao WP^*. CSMD1 as a causative gene of developmental and epileptic encephalopathy and generalized epilepsies. Genes Dis. 2024 Nov 29;12(4):101473. doi: 10.1016/j.gendis.2024.101473. eCollection 2025 Jul. PMID: 40330149.

Jiao JP^#, Zhang HW^#, Zhou XZ^#, Tian SJ, Gao L, Li BM, Luo JX, Wang J, Lan S, Li B^*, Liao WP^*. Missense variants in SLC9A6 cause partial epilepsy without neurodevelopmental delay. Orphanet J Rare Dis. 2025 Jul 28;20(1):380. doi: 10.1186/s13023-025-03924-9. PMID: 40722028.

Tian Y^#, Hou YQ^#, Zhai QX, Song XW, Li BM, Wang J, Ji JJ, Liao YT, Chen WX, Li B^*, Liao WP^*. RYR3 Variants Are Potentially Associated With Idiopathic (Non-Lesional) Partial Epilepsy/Susceptibility of Seizures, Toward Understanding the Gene-Disease Association by Genetic Dependent Nature. Am J Med Genet B Neuropsychiatr Genet. 2025 Jul;198(5):e33023. doi: 10.1002/ajmg.b.33023. Epub 2025 Jan 22. PMID: 39840699.

Ji L^#, Yan J^#, Losurdo NA^#, Wang H, Liu L, Li K, Liu Z, Guo Z, Xu J, Bibo A, Ren D, Yang K, Luo Y, Yang F, Wang G, Xiang Z, Wang Y, Zhan H, Pan H, Hu J, Zhong J, Abou Jamra R, Zacher P, Musante L, Faletra F, Costa P, Zanus C, Couque N, Ruaud L, Cueto-González AM, San Nicolas Fernández H, Tizzano E, Martinez Gil N, Liu X, Liao W, Abi Farraj L, Huang AY, Zhang L, Murali A, Schmuel E, Han CS, King K, Gu W, Wang P, Li K, Link N, He G^*, Bian S^*, Mao X^*. Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly. J Clin Invest. 2025 Jul 3;135(18):e186119. doi: 10.1172/JCI186119. eCollection 2025 Sep 16. PMID: 40608414.

Lei XY^#, Zhang MW^#, Sun H^#, Song W, Liang XY, Wang CS, Luo S, Li BM, Liu XR, Wang Y, Tian Y, Peng Q, Wang J, Meng H^*, He N^*, Liao WP. Identification of MACF1 as a causative gene of generalised epilepsy. J Med Genet. 2025 Jun 24;62(7):484-493. doi: 10.1136/jmg-2025-110699. PMID: 40350249.

Ji J, Zhou X, Lu Y, Shen L, Li L, Chen Z, Shi Y, Liao W, Yu L^*. SCN1A intronic variants impact on Nav1.1 protein expression and sodium channel function, and associated with epilepsy phenotypic severity. Gene. 2025 Jan 10;932:148876. doi: 10.1016/j.gene.2024.148876. Epub 2024 Aug 22. PMID: 39173978.

Wen Q^#, Zhang D^#, Ding Y^#, Luo S, Huang Q, Zhu J, Li Y, Liu W, Wang P, Li X, Lin Z, Wang Y, Liang X, Liao W, Wang J^*, Meng H^*. MDN1 variants cause susceptibility to epilepsy: For the China Epilepsy Gene 1.0 Project. Acta Epileptol. 2025 Mar 3;7(1):17. doi: 10.1186/s42494-025-00209-3. PMID: 40217384.

Shen N^#, Zhuo Z^#, Luo X, Li B, Lin X, Luo S, Ye Z, Wang P, He N, Shi Y^*, Liao W^*. Variants of TSC1 are associated with developmental and epileptic encephalopathy and focal epilepsy without tuberous sclerosis: For the China Epilepsy Gene 1.0 Project. Acta Epileptol. 2024 Nov 29;6(1):41. doi: 10.1186/s42494-024-00189-w. PMID: 40217423.

Zhang M^#, Guo J^#, Li B, Liu K, Zhao J, Zhang J, Lin X, Tang B, Wang J, Liao W^*, He N^*. Characteristic spatial and frequency distribution of mutations in SCN1A. Acta Epileptol. 2024 Nov 11;6(1):37. doi: 10.1186/s42494-024-00178-z. PMID: 40217529.

Zhang D^#, Guo J^#, Lin Z^#, Yan H, Peng K, Fei L, Zhai Q, Zou D, Zhong J, Ding Y, Ye H, Wang P, Wang J, Luo S, Li B, Li B^*, Liao W^*. SLC2A1 variants cause late-onset epilepsy and the genetic-dependent stage feature: For the China Epilepsy Gene 1.0 Project. Acta Epileptol. 2024 Nov 7;6(1):38. doi: 10.1186/s42494-024-00177-0. PMID: 40217381.

Luo J^#, Li Y^#, Lv Y, Li X, Qin B, Cheng C, Liu X, Liao WP, Wang J^*, Gao Z^*. MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation. Genes Dis. 2023 Jul 13;11(3):101032. doi: 10.1016/j.gendis.2023.06.006. eCollection 2024 May. PMID: 38292201.

Hu YY, Song W, Liu ZG, Ye XG, Zhang HW, Li X, Luo JX, Wang PY, Wang J, Lin XF, Zhu HL, Liao WP, Li B^*, Chen XQ^*. ARHGAP4 variants are associated with X-linked early-onset temporal lobe epilepsy. World J Pediatr. 2024 Aug;20(8):859-867. doi: 10.1007/s12519-024-00830-1. Epub 2024 Jul 26. PMID: 39060771.

Shen NX^#, Qu XC^#, Yu J, Fan CX, Min FL, Li LY, Zhang MR, Li BM, Wang J, He N, Liao WP, Shi YW^*, Li WB^*. NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation. Mol Neurobiol. 2024 Nov;61(11):8518-8530. doi: 10.1007/s12035-024-04123-6. Epub 2024 Mar 23. PMID: 38520610.

Li SX^#, He N^#, Liao JX, Lu XG, Hu WG, Liu XR, Liao WP, Song XW^*, Li B^*. Association of LONP1 gene with epilepsy and the sub-regional effect. Sci Rep. 2024 Oct 26;14(1):25575. doi: 10.1038/s41598-024-77039-9. PMID: 39462050.

Song W^#, Bian WJ^#, Li H, Guo QH, Wang J, Tang B, Zhang JY, Wei W, Liu XR, Liao WP, Li B^*, He N^*. IFIH1 variants are associated with generalised epilepsy preceded by febrile seizures. J Med Genet. 2024 Aug 29;61(9):895-903. doi: 10.1136/jmg-2024-109950. PMID: 38964834.

He MF^#, Liu LH^#, Luo S^#, Wang J, Guo JJ, Wang PY, Zhai QX, He SL, Zou DF, Liu XR, Li BM, Ma HY, Qiao JD, Zhou P, He N^*, Yi YH^*, Liao WP. ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favourable outcomes. J Med Genet. 2024 Jun 20;61(7):652-660. doi: 10.1136/jmg-2023-109725. PMID: 38508705.

Wu WC^#, Liang XY^#, Zhang DM, Jin L, Liu ZG, Zeng XL, Zhai QX, Liao WP, He N^*, Meng XH^*. DYNC1H1 variants associated with infant-onset epilepsy without neurodevelopmental disorders. Seizure. 2024 Mar;116:119-125. doi: 10.1016/j.seizure.2023.10.010. Epub 2023 Oct 27. PMID: 37903666.

Chen YJ^#, Wang WJ^#, Zou DF, Luo JX, Jin PY, Jin L, Liu XR, Liao WP, Li B^*, Chen YJ^*; China Epilepsy Gene 1.0 Project. CCDC88C variants are associated with focal epilepsy and genotype-phenotype correlation. Clin Genet. 2024 Apr;105(4):397-405. doi: 10.1111/cge.14476. Epub 2024 Jan 3. PMID: 38173219.

Tian MQ^#, Liu XR^#, Lin SM^#, Wang J, Luo S, Gao LD, Chen XB, Liang XY, Liu ZG, He N, Yi YH, Liao WP^*; China Epilepsy Gene 1.0 Project. Variants in BRWD3 associated with X-linked partial epilepsy without intellectual disability. CNS Neurosci Ther. 2023 Feb;29(2):727-735. doi: 10.1111/cns.14057. Epub 2022 Dec 13. PMID: 36514184.

Ye T^#, Zhang J^#, Wang J, Lan S, Zeng T, Wang H, He X, Li BM, Deng W, Liao WP^*, Liu XR^*. Variants in BSN gene associated with epilepsy with favourable outcome. J Med Genet. 2023 Aug;60(8):776-783. doi: 10.1136/jmg-2022-108865. Epub 2022 Dec 12. PMID: 36600631.

Du S^#, Zeng S^#, Song L^#, Ma H, Chen R, Luo J, Wang X, Ma T, Xu X, Sun H, Yi P, Guo J, Huang Y, Liu M, Wang T, Liao WP, Zhang L^*, Liu JY^*, Tang B^*. Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy. Sci China Life Sci. 2023 Sep;66(9):2152-2166. doi: 10.1007/s11427-022-2313-1. Epub 2023 Apr 12. PMID: 37071290.

He YY^#, Luo S^#, Jin L, Wang PY, Xu J, Jiao HL, Yan HJ, Wang Y, Zhai QX, Ji JJ, Zhang WJ, Zhou P, Li H, Liao WP, Lan S^*, Xu L^*. DLG3 variants caused X-linked epilepsy with/without neurodevelopmental disorders and the genotype-phenotype correlation. Front Mol Neurosci. 2024 Jan 5;16:1290919. doi: 10.3389/fnmol.2023.1290919. eCollection 2023. PMID: 38249294.

Mullan KA, Anderson A, Shi YW, Ding JH, Ng CC, Chen Z, Baum L, Cherny S, Petrovski S, Sham PC, Lim KS, Liao WP^*, Kwan P^*. Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti-seizure medications. Epilepsia. 2022 Apr;63(4):936-949. doi: 10.1111/epi.17182. Epub 2022 Feb 16. PMID: 35170024.

Luo S^#, Liu ZG^#, Wang J, Luo JX, Ye XG, Li X, Zhai QX, Liu XR, Wang J, Gao LD, Liu FL, Ye ZL, Li H, Gao ZF, Guo QH, Li BM, Yi YH, Liao WP^*. Recessive LAMA5 Variants Associated With Partial Epilepsy and Spasms in Infancy. Front Mol Neurosci. 2022 May 19;15:825390. doi: 10.3389/fnmol.2022.825390. eCollection 2022. PMID: 35663266.

Li X, Bian WJ, Liu XR, Wang J, Luo S, Li BM, Yi YH, Wu QY, Zhai QX, Gao LD, Zhang HF, He N, Liao WP^*; China Epilepsy Gene 1.0 Project. BCOR variants are associated with X-linked recessive partial epilepsy. Epilepsy Res. 2022 Nov;187:107036. doi: 10.1016/j.eplepsyres.2022.107036. Epub 2022 Oct 19. PMID: 36279688.

Zheng Chen^#, Sheng Luo^#, Zhi-Gang Liu^#, Yan-Chun Deng, Su-Li He, Xiao-Rong Liu, Yong-Hong Yi, Jie Wang, Liang-Di Gao, Bing-Mei Li, Zhi-Jun Wu, Zi-Long Ye, De-Hai Liang, Wen-Jun Bian, Liao WP^*, For the China Epilepsy Gene 1.0 Project. CELSR1 variants are associated with partial epilepsy of childhood. Am J Med Genet B Neuropsychiatr Genet. 2022 Oct;189(7-8):247-256. doi: 10.1002/ajmg.b.32916. Epub 2022 Aug 12. PMID: 36453712.

Wang JY^#, Wang J^#, Lu XG, Song W, Luo S, Zou DF, Hua LD, Peng Q, Tian Y, Gao LD, Liao WP, He N^*. Recessive PKD1 Mutations Are Associated With Febrile Seizures and Epilepsy With Antecedent Febrile Seizures and the Genotype-Phenotype Correlation. Front Mol Neurosci. 2022 May 10;15:861159. doi: 10.3389/fnmol.2022.861159. eCollection 2022. PMID: 35620448.

Tian Y^#, Zhai QX^#, Li XJ^#, Shi Z, Cheng CF, Fan CX, Tang B, Zhang Y, He YY, Li WB, Luo S, Hou C, Chen WX^*, Liao WP, Wang J^*. ATP6V0C Is Associated With Febrile Seizures and Epilepsy With Febrile Seizures Plus. Front Mol Neurosci. 2022 May 6;15:889534. doi: 10.3389/fnmol.2022.889534. eCollection 2022. PMID: 35600075.

Liu XR^#, Xu XX^#, Lin SM, Fan CY, Ye TT, Tang B, Shi YW, Su T, Li BM, Yi YH, Luo JH^*, Liao WP^*. GRIN2A Variants Associated With Idiopathic Generalized Epilepsies. Front Mol Neurosci. 2021 Oct 14;14:720984; PMCID: PMC8551482. PMID: 34720871.

Su T^#, Chen ML^#, Liu LH, Meng H, Tang B, Liu XR, Liao WP^*. Critical Role of E1623 Residue in S3-S4 Loop of Nav1.1 Channel and Correlation Between Nature of Substitution and Functional Alteration. Front Mol Neurosci. 2022 Jan 10;14:797628. doi: 10.3389/fnmol.2021.797628. eCollection 2021. PMID: 35082603.

Ma MG^#, Liu XR^#, Wu Y, Wang J, Li BM, Shi YW, Su T, Li B, Liu DT, Yi YH^*, Liao WP^*. RYR2 Mutations Are Associated With Benign Epilepsy of Childhood With Centrotemporal Spikes With or Without Arrhythmia. Front Neurosci. 2021 Apr 7;15:629610. doi: 10.3389/fnins.2021.629610. PMID: 33897349.

Ye XG^#, Liu ZG^#, Wang J, Dai JM, Qiao PX, Gao PM, Liao WP^*. YWHAG Mutations Cause Childhood Myoclonic Epilepsy and Febrile Seizures: Molecular Sub-regional Effect and Mechanism. Front Genet. 2021 Mar 9;12:632466; PMCID: PMC7985244. PMID: 33767733.

Liu XR, Bian WJ, Wang J, Ye TT, Li BM, Liu DT, Tang B, Deng WW, Shi YW, Su T, Yi YH, Liao WP^*. Heterozygous PGM3 Variants Are Associated With Idiopathic Focal Epilepsy With Incomplete Penetrance. Front Genet. 2020 Oct 15;11:559080; PMCID: PMC7597759. PMID: 33193641.

Wei F, Yan L-M, Su T, Na H, Lin Z-J, Wang J, Shi Y-W, Yi Y-H, Liao W-P^*. Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy. Neuroscience Bulletin. 2017 Aug;33(4):455-477; PMCID: PMC5567559. PMID: 28488083.

Gao QW, Hua LD, Wang J, Fan CX, Deng WY, Li B, Bian WJ, Shao CX, He N, Zhou P, Liao WP^*, Shi YW^*. A Point Mutation in SCN1A 5' Genomic Region Decreases the Promoter Activity and Is Associated with Mild Epilepsy and Seizure Aggravation Induced by Antiepileptic Drug. Mol Neurobiol. 2017 May;54(4):2428-2434. PMID: 26969601.

Wang J, Lin ZJ, Liu L, Xu HQ, Shi YW, Yi YH, He N, Liao WP^*. Epilepsy-associated genes. Seizure. 2017 Jan;44:11-20. PMID: 28007376.

Xiao-Rong Liu, Dan Huang, Jie Wang, Yi-Fan Wang, Hui Sun, Bin Tang, Wen Li, Jin-Xing Lai, Na He, Mei Wu, Tao Su, Heng Meng, Yi-Wu Shi, Bing-Mei Li, Bei-Sha Tang, Liao WP^*. Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene. Neurol Genet. 2016 Apr; 2(2): e66; PMCID: PMC4830198. PMID: 27123484.

Chen YJ, Shi YW, Xu HQ, Chen ML, Gao MM, Sun WW, Tang B, Zeng Y, Liao WP^*. Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A. Mol Neurobiol. 2015 Jun;51(3):1263-1270. PMID: 24990319.

Liu T, Wan RP, Tang LJ, Liu SJ, Li HJ, Zhao QH, Liao WP, Sun XF, Yi YH, Long YS. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Mol Neurobiol. 2015;51(3):1053-63. PMID: 24906954.

Dong ZF, Tang LJ, Deng GF, Zeng T, Liu SJ, Wan RP, Liu T, Zhao QH, Yi YH, Liao WP, Long YS. Transcription of the Human Sodium Channel SCN1A Gene Is Repressed by a Scaffolding Protein RACK1. Mol Neurobiol. 2014 Oct;50(2):438-48. PMID: 24436055.

Zeng T, Dong ZF, Liu SJ, Wan RP, Tang LJ, Liu T, Zhao QH, Shi YW, Yi YH, Liao WP, Long YS. A novel variant in the 3' UTR of human SCN1A gene from a patient with Dravet syndrome decreases mRNA stability mediated by GAPDH's binding. Hum Genet. 2014 Jun;133(6):801-11. PMID: 24464349.

Liu XR, Wu M, He N, Meng H, Wen L, Wang JL, Zhang MP, Li WB, Mao X, Qin JM, Li BM, Tang B, Deng YH, Shi YW, Su T, Yi YH, Tang BS, Liao WP^*. Novel PRRT2 mutations in paroxysmal dyskinesia patients with variant inheritance and phenotypes. Genes Brain Behav. 2013 Mar;12(2):234-40. PMID: 23190448.

Deng GF, Liu SJ, Sun XS, Sun WW, Zhao QH, Liao WP, Yi YH, Long YS. A conserved region in the 3' untranslated region of the human LIMK1 gene is critical for proper expression of LIMK1 at the post-transcriptional level. Neurosci Bull. 2013;29(3):348-54. PMID: 23700283.

Lv YD, Min FL, Liao WP, He N, Zeng T, Ma DH, Shi YW. The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a northern Han Chinese population. BMC Neurol. 2013; 13: 75. PMID: 23829937.

Wang JL, Mao X, Hu ZM, Li JD, Li N, Guo JF, Jiang H, Shen L, Li J, Shi YT, Xia K, Liu JY, Liao WP, Tang BS. Mutation analysis of PRRT2 in two Chinese BFIS families and nomenclature of PRRT2 related paroxysmal diseases. Neurosci Lett. 2013 Sep 27;552:40-5. PMID: 23896529.

Shi YW, Min FL, Qin B, Zou X, Liu XR, Gao MM, Wang Q, Zhou JQ, Liao WP^*. Association between HLA and Stevens-Johnson Syndrome Induced by Carbamazepine in Southern Han Chinese: Genetic Markers besides B*1502? Basic Clin Pharmacol Toxicol. 2012 Jul;111(1):58-64. Epub 2012 Mar 17. PMID: 22348435.

He N, Min FL, Shi YW, Guo J, Liu XR, Li BM, Zhou JH, Ou YM, Liao JX, Liao WP^*. Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: incidence, features, risk factors and relation to HLA-B alleles. Seizure 2012 Oct; 21(8):614-8. PMID: 22818943.

Shi YW, Yu MJ, Long YS, Qin B, He N, Meng H, Liu XR, Deng WY, Gao MM, Yi YH, Li BM, Liao WP^*. Mosaic SCN1A mutations in familial partial epilepsy with antecedent febrile seizures. Genes Brain Behav. 2012 Mar;11(2):170-6. PMID: 22151702.

Shi YW, Min FL, Liu XR, Zan LX, Gao MM, Yu MJ, Liao WP^*. Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population. Basic Clin Pharmacol Toxicol 2011 Jul;109(1):42-6. PMID: 21306565.

Long YS, Deng GF, Sun XS, Yi YH, Su T, Zhao QH, Liao WP^*. Identification of the transcriptional promoters in the proximal regions of human microRNA genes. Mol Biol Rep. 2011 Aug;38(6):4153-7. PMID: 21107707.

Li BM, Liu XR, Yi YH, Deng YH, Su T, Zou X, Liao WP^*. Autism in Dravet syndrome: prevalence, features, and relationship to the clinical characteristics of epilepsy and mental retardation. Epilepsy Behav. 2011 Jul;21(3):291-5. PMID: 21620773.

Long YS, Qin JM, Su T, Zhao QH, Yi YH, Liao WP. Human transcription factor genes involved in neuronal development tend to have high GC content and CpG elements in the proximal promoter region. J Genet Genomics 2011 Apr 20;38(4):157-63. PMID: 21530899.

Su T, Paradiso B, Long YS, Liao WP, Simonato M. Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection. Brain Res 2011 Apr 18;1385:68-76. PMID: 21303673.

Deng GF, Qin JM, Sun XS, Kuang ZY, Su T, Zhao QH, Shi YW, Liu XR, Yu MJ, Yi YH, Liao WP, Long YS. Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation. J Mol Neurosci. 2011 Jun;44(2):115-21. PMID: 21271300.

Wang YL, Zeng ZY, Song XW, Hao ZF, Shi YW, Tang B, Chen SQ, Gao MM, Di W, Long YS, Yi YH, Liao WP. A novel CLN2/TPP1 mutation in a Chinese patient with late infantile neuronal ceroid lipofuscinosis. Neurogenetics. 2011 Feb;12(1):93-5. PMID: 20820830.

Liao WP^*, Yi-Wu Shi, Yue-Sheng Long, Yang Zeng, Tian Li, Mei-Juan Yu, Tao Su, Ping Deng, Zhi-Gang Lei, Shu-Jun Xu, Wei-Yi Deng, Xiao-Rong Liu, Wei-Wen Sun, Yong-Hong Yi, Zao C. Xu, Shumin Duan. Partial epilepsy with antecedent febrile seizures and seizure aggravation by antiepileptic drugs: associated with loss of function of Na(v) 1.1. Epilepsia. 2010 Sep;51(9):1669-1678. doi: 10.1111/j.1528-1167.2010.02645.x. PMID: 20550552.

Yu MJ, Shi YW, Gao MM, Deng WY, Liu XR, Chen L, Long YS, Yi YH, Liao WP^*. Milder phenotype with SCN1A truncation mutation other than SMEI. Seizure. 2010 Sep;19(7):443-5. PMID: 20630778.

Long YS, Huang MQ, Liao WP. Identification of novel cyclic nucleotide phosphodiesterase gene cDNAs in the brain of guinea pig. Neurosci Bull. 2010 Oct;26(5):365-70. doi: 10.1007/s12264-010-0517-z; PMCID: PMC5560350. PMID: 20882062.

Yi YH, Sun XS, Qin JM, Zhao QH, Liao WP, Long YS^*. Experimental identification of microRNA targets on the 3' untranslated region of human FMR1 gene. J Neurosci Methods. 2010 Jun 30;190(1):34-8. PMID: 20435064.

Yue-Sheng Long, Yi-Wu Shi, Liao WP^*. Conservation-based prediction of the transcription regulatory region of SCN1A. Prog Nat Sci 2009, 19(12):1675-1681.

Yue-Sheng Long, Qi-Hua Zhao, Tao Zeng, Wei-Wen Sun, Liao WP^*. Characterization of The Promoter Region and Upstream Regulation Region of Human and Mouse SCN3A Gene. Prog Biochem Biophys 2009; 36(3):339-345.

LF Qiu, TJ Lu, XL Hu, YH Yi, Liao WP, ZQ Xiong^*. Limbic epileptogenesis in a mouse model of fragile X syndrome. Cereb Cortex. 2009 Jul;19(7):1504-1514. doi: 10.1093/cercor/bhn163. PMID: 18832330.

Yi YH, Guo WC, Sun WW, Su T, Lin H, Chen SQ, Deng WY, Zhou W, Liao WP^*. Neuroprotection of lamotrigine on hypoxic-ischemic brain damage in neonatal rats: Relations to administration time and doses. Biologics 2008; 2(2):339-44. PMID: 19707366.

Su T, Cong WD, Long YS, Luo AH, Sun WW, Deng WY, Liao WP^*. Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. Neuroscience. 2008 Dec 2;157(3):566-76. PMID: 18930118.

Long YS, Zhao QH, Su T, Cai YL, Zeng Y, Shi YW, Yi YH, Chang HH, Liao WP^*. Identification of the promoter region and the 5'-untranslated exons of the human voltage-gated sodium channel Nav1.1 gene (SCN1A) and enhancement of gene expression by the 5'-untranslated exons. J Neurosci Res. 2008 Nov 15;86(15):3375-81. PMID: 18655196.

Liao WP^*, Yi-Wu Shi, Bing Qin, Tian Li, Mei-Juan Yu, Yu-Hong Deng, Xiao-Rong Liu, Yong-Hong Yi, Lun-Jiao Fu, Wi-Yi Deng, Bing-Mei Li, Tao Su, Yue-Sheng Long. Partial epilepsy with febrile seizure plus: A subtype of GEFS+ or SME? Neurology Asia 2007;12(Supplement 1):78–79.

Liao WP^*. Antiepileptic drug trials with greater attention to daily clinical practice and special epilepsy syndromes. Neurology Asia 2007; 12(Supplement 1):30–32.

Wei ZX, Yi YH^*, Sun WW, Wang R, Su T, Bai YJ, Liao WP. Expression changes of microtubule associated protein 1B in the brain of Fmr1 knockout mice. Neurosci Bull. 2007 Jul;23(4):203-8. PMID: 17687394.

Su T, Luo AH, Cong WD, Sun WW, Deng WY, Zhao QH, Zhang ZH, Liao WP^*. Immunohistochemical investigation of voltage-gated potassium channel-interacting protein 1 in normal rat brain and Pentylenettrazole-induced seizures. Neurosci Bull. 2006 Jul;22(4):195-203. PMID: 17704832.

Chang HH, Su T, Sun WW, Zhao QH, Qin B, Liao WP^*. Changes of potassium channels Kv4.2, Kv4.3 and Kv channel interacting protein 1 in amygdala kindling epilepsy: experiment with rats. Zhonghua Yi Xue Za Zhi. 2006 Dec 19;86(47):3315-8. PMID: 17313824.

Liao WP^*, Chen L, Yi YH, Sun WW, Gao MM, Su T, Yang SQ. Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. Epilepsia. 2005;46 Suppl 1:21-4. PMID: 15816974.

Liao WP^*, Shao-Qing Yang, Yong-Hong Yi, et al. An open-label study of topiramate as add-on therapy for epilepsy using slow titration. Neurology Asia 2005, 10:99-104.

Yi YH, Liao WP, Lu X. Simultaneous determination of tryptophan, 5-hydroxytryptophan, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, 4-hydroxy-3-methoxyphenylacetic acid and 3-methoxy-4-hydroxyphenylglycol in human cerebrospinal fluid. J Chromatogr B Biomed Appl. 1994 Nov 4;661(1):143-8. PMID: 7532522.

Liang S, Fan X, Kuang S, You G, Liu T, Zhang J, Zhang W, You Y, Deng Y, Ma W, Lin Y, Qian R, Lin W, Wang L, Zhang C, Guan Y, Yan Z, Yang X, Li W, Yue W, Zhang H, Sun D, Liu Y, Wang Z, Li H, Han X, Wang Y, Wang Y, Liao W, Cai L, Huang G, Chen Y, Chen J, Liu X, Peng J, Chen Z, Chen L, Zhang G, Zhang J, Qiu X, Zhao G, Jiang C, Chu L, Mou Y, Chen L, Zhu S, Wu A, Zhang N, Li S, Wu J, Wang S, Wang Y, Li S, Zhou D, Jiang T. Clinical practice guidelines for the diagnosis and treatment of diffuse glioma-related epilepsy: 2025 update. Cancer Lett. 2026 May 1;645:218360. doi: 10.1016/j.canlet.2026.218360. Epub 2026 Feb 23. PMID: 41740829.

Yan R^#, Zhang H^#, Hong Z, Liao W, Wang X, Wang Y, Xiao B, Deng Y, Ding M, Han X, Liang S, Lin W, Liu X, Liu X, Wang X, Wang T, Wang X, Wang X, Yu P, Zhang K, Zhou J, Zhou L, Zhou S, Zhu G, Zhu S, Wu X^*, Zhou D^*. Sodium channel blockers for the treatment of focal epilepsy: A Chinese expert consensus. Seizure. 2025 Apr;127:105-114. doi: 10.1016/j.seizure.2025.02.016. Epub 2025 Mar 12. PMID: 40121855.

Mu J, Jiang W, Tang Y, Zhou D, Liao W^*. Precision gene diagnosis and treatment of epilepsy: a new frontier in medical care. Acta Epileptol. 2025 Oct 1;7(1):46. doi: 10.1186/s42494-025-00241-3. PMID: 41029448.

Tian Y, Zhai QX, Li XJ, Shi Z, Cheng CF, Fan CX, Tang B, Zhang Y, He YY, Li WB, Luo S, Hou C, Chen WX^*, Liao WP, Wang J^*. Corrigendum: ATP6V0C is associated with febrile seizures and epilepsy with febrile seizures plus. Front Mol Neurosci. 2024 Mar 1;17:1385915. doi: 10.3389/fnmol.2024.1385915. eCollection 2024. PMID: 38495552.

Paradiso B^*, Limback C, Su T, Liao W, Mpotsaris A. Editorial: An update on neurological disorders post COVID-19 infection. Front Neurol. 2023 Jul 13;14:1229843. doi: 10.3389/fneur.2023.1229843. eCollection 2023. PMID: 37521288.

Liao WP^*, Chen Q, Jiang YW, Luo S, Liu XR. Editorial: Sub-molecular mechanism of genetic epilepsy. Front Mol Neurosci. 2022 Jul 26;15:958747. doi: 10.3389/fnmol.2022.958747. eCollection 2022. PMID: 35959103.

He H, Stauber T, Liao W, Jiang Y, Yu Y, Peng J^*. Editorial: Ion channels and transporters in epilepsy: From genes and mechanisms to disease-targeted therapies. Front Mol Neurosci. 2022 Sep 21;15:1011843. doi: 10.3389/fnmol.2022.1011843. eCollection 2022. PMID: 36211977.

Liao WP^*, Shi YW, Min FL. HLA-B*1502 screening and toxic effects of carbamazepine. N Engl J Med. 2011 Aug 18;365(7):672-3; author reply 673. PMID: 21848471.

Min FL, Shi YW, Liu XR, Liao WP. HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome. Epilepsy Behav. 2011 Feb;20(2):390-1. doi: 10.1016/j.yebeh.2010.11.022. Epub 2011 Jan 7. PMID: 21216202.

Zhou P, He N, Lin ZJ, Yan LM, Luo S, Li B, Wang J, Bian WJ, Meng H, Shi YW, Su T, Liu XR, Yi YH, Liao WP^*. Clinical concordance evaluation of the causality of sequence variants. Research Square [Preprint]. 2023 Sep 18. Version 2. doi: 10.21203/rs.3.rs-3270536/v2.