徐恩

教授、博士生导师

从事神经病学专业教学、科研、医疗工作31年,现任中华医学会神经病学分会脑血管病学组委员,中国医师协会神经内科医师分会脑血管病专业委员会委员,广东省医学会神经病学分会常委和脑血管病学组副组长,广州医学会神经病分会副主任委员。

多年来一直从事脑缺血和脑缺氧的基础及应用研究,于1997-1999年在美国迈阿密大学医学院进修,从事脑血管病基础研究。目前正在带领包括15人的研究团队从事缺血性脑血管病研究。已培养硕士研究生30余名,博士研究生2名,其中多名研究生在校期间被评为优秀研究生,2名学生荣获“国家研究生奖学金”,1名学生获“广东省优秀硕士毕业论文”。

多年来,作为主要负责人承担并完成了包括国家自然基金在内的国家、省部级的科研课题及国际合作研究课题,作为第一完成人完成了《广东中山古镇心脑血管病社区人群综合防治系列研究》获广东省和广州市科技进步奖各一项。在国内外重要期刊发表论文150多篇,其中有25篇论文被SCI收录,作为通讯作者发表的SCI收录文章13篇。近年来已取得的研究工作成绩如下:

近5年来已发表的主要论著目录 作为通讯作者发表的文章

  1. Tingna Zhu, Lixuan Zhan, Donghai Liang, Jiaoyue Hu, Zhiwei Lu, Xinyong Zhu, Weiwen Sun, Liu Liu, MD, and En Xu*. Hypoxia-inducible factor 1alpha mediates neuroprotection of hypoxic postconditioning against global cerebral ischemia. J Neuropathol Exp Neurol. 2014; 73(10): 975-86.
  2. Lixuan Zhan, Hongxin Yan, Huarong Zhou, Weiwen Sun, Qinghua Hou, En Xu*. Hypoxic Preconditioning Attenuates Neuronal Cell Death by Preventing MEK/ERK Signaling Pathway Activation after Transient Global Cerebral Ischemia in Adult Rats. Molecular Neurobiology 2013; 48: 109-119.
  3. Zhu P, Zhan L, Zhu T, Hu J, Sun W, Hou Q, Wu B, Wang Y, Xu E*. The Roles of p38 MAPK/MSK1 Signaling Pathway in the Neuroprotection of Hypoxic Postconditioning against Transient Global Cerebral Ischemia in Adult Rats. Mol Neurobiol. 2014, 49(3): 1338-1349.
  4. Zhan L, Li D, Liang D, Wu B, Zhu P, Wang Y, Sun W, Xu E*. Activation of Akt/FoxO and Inactivation of MEK/ERK Pathways Contribute to Induction of Neuroprotection against Transient Global Cerebral Ischemia by Delayed Hypoxic Postconditioning in Adult Rats. Neuropharmacology ?2012; 63 :873-882
  5. Zhan L, Peng W, Sun W, Xu E*. Hypoxic Preconditioning Induces Neuroprotection against Transient Global Ischemia in Adult Rats via Preserving the Activity of Na+/K+-ATPase. Neurochem Int . ?2011;59:65–72
  6. Wang Y, Zhan L, Zeng W, Li K, Sun W, Xu ZC, Xu E*. Downregulation of Hippocampal GABA After Hypoxia-Induced Seizures In Neonatal Rats. Neurochem Res 2011; 36:2409-2416
  7. Peng Z, Zhan L, Chen S, Xu E*. Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese. Lipids Health Dis ?2011,10:100
  8. Zhan L, Wang T, Li W, Xu ZC, Sun W, Xu E*. Activation of Akt/FOXO Signaling Pathway Contributes to Induction of Neuroprotection against Transient Global Cerebral Ischemia by Hypoxic Preconditioning in Adult Rats. J Neurochem. 2010; 114: 897–908.
  9. Xu E*. Li W, Zhan Z, Guan G, Wang X, Chen S, Shi Y. Polymorphisms of LPL Gene are Associated with Atherosclerotic Cerebral Infarction in the Chinese. Neuroscience. 2008; 155: 403-408
  10. Wang X,Sun W, Xu E*. Lipoprotein lipase protein expression and activity is increased after acute cerebral ischemia/reperfusion in rats. Neuropathology. 2010; 30:131-139
  11. Xu E*, Wang X, Hao Z, ChenZ, Lu X. Germinoma in the basal ganglia with an abnormal constitutional karyotype: Case study and review of the literature. Childs Nerv Syst. 2010; 26:707-712
  12. GUO JJ, Xu E*, Qing-Yuan LIN, Guo-Ling ZENG, Hai-Feng XIE. Effect of Cilostazol on Cerebral Arteries in Secondary Prevention of Ischemic Stroke. Neurosci Bull. 2009; 25(6):383-390.
  13. Li K, Xu E*. The role and the mechanism of amma-aminobutyric acid during central nervous system development . Neurosci Bull. 2008; 24: 195-200.

 

* : Corresponding author

 

 

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