基因表达调控与神经系统疾病研究组

 

龙跃生

博士,博士后学历,教授,博士生导师,广东省“千百十工程”国家级培养对象

联系方式:

地址:广州市海珠区昌岗东路250号 广州医科大学附属第二医院神经科学研究所

邮编:510260 电话:020-34152640

E-mail:longyuesheng[at]gzhmu.edu.cn

     

课题组主要成员:

赵绮华(研究助理,高级实验师) 万瑞平(博士生) 周林涛 (博士生) 刘淑靖(硕士生)汤凌佳 (硕士生)林国旺 (硕士生)谭娜娜 (硕士生)周雍庭 (硕士生)唐慧玲 (硕士生)

主要研究兴趣:

    1生酮饮食抗癫痫的分子机制。

    2能量代谢调节在癫痫发生发展过程中的作用机制。

     (3智力发育相关基因的表达调控机制及其与疾病的相关性。

 

近期发表的代表性论文:(* 责任作者,并列第一作者)   

[1]. Li HJ#, Wan RP#, Tang LJ, Liu SJ, Zhou LT, Zhao QH, Yi YH, Liao WP, Sun SF*, Long YS*. Alteration of Scn3a expression is mediated via CpG methylation and MBD2 in mouse hippocampus during postnatal development and seizure condition. BBA-Gene Regulatory Mechanisms, 2014 Aug. [Revision submitted]. (IF=5.4)
[2]. Liu T#, Wan RP#, Tang LJ, Liu SJ, Li HJ, Zhao QH, Liao WP, Sun XF, Yi YH*, Long YS*. A microRNA profile in Fmr1 knockout mice reveals microRNA expression alterations with possible roles in fragile X syndrome. Mol Neurobiol, 2014 Jun 7. [Epub ahead of print]. (IF=5.7)
[3]. Dong ZF#, Tang LJ#, Deng GF, Zeng T, Liu SJ, Wan RP, Liu T, Zhao QH, Yi YH, Liao WP, Long YS*. Transcription of the Human Sodium Channel SCN1A Gene Is Repressed by a Scaffolding Protein RACK1. Mol Neurobiol. 2014 Jan 17. [Epub ahead of print]. (IF=5.7)
[4]. Zeng T, Dong ZF, Liu SJ, Wan RP, Tang LJ, Liu T, Zhao QH, Shi YW, Yi YH, Liao WP, Long YS*. A novel variant in the 3' UTR of human SCN1A gene from a patient with Dravet syndrome decreases mRNA stability mediated by GAPDH抯 binding. Hum Genet. 2014; 133(6):801-11. (IF=5.0)
[5]. Deng GF#, Liu SJ#, Sun XS, Sun WW, Zhao QH, Liao WP, Yi YH*, Long YS*. A conserved region in the 3' untranslated region of the human LIMK1 gene is critical for proper expression of LIMK1 at the post-transcriptional level. Neurosci Bull. 2013; 29(3):348-54. (IF=1.8)
[6]. Long YS*, Qin JM, Su T, Zhao QH, Yi YH, Liao WP. Human transcription factor genes involved in neuronal development tend to have high GC content and CpG elements in the proximal promoter region. J Genet Genomics. 2011; 38(4):157-63. (IF=2.9)
[7]. Deng GF#, Qin JM#, Sun XS, Kuang ZY, Su T, Zhao QH, Shi YW, Liu XR, Yu MJ, Yi YH, Liao WP, Long YS*. Promoter Analysis of Mouse Scn3a Gene and Regulation of the Promoter Activity by GC Box and CpG Methylation. J Mol Neurosci. 2011; 44(2):115-21. (IF=2.9)
[8]. Long YS*, Deng GF, Sun XS, Yi YH, Su T, Zhao QH, Liao WP. Identification of the transcriptional promoters in the proximal regions of human microRNA genes. Mol Biol Rep. 2011; 38(6):4153-7. (IF=2.5)
[9]. Long YS*, Huang MQ, Liao WP. Identification of novel cyclic nucleotide phosphodiesterase gene cDNAs in the brain of guinea pig. Neurosci Bull. 2010; 26(5):365-70. (IF=1.3)
[10]. Yi YH#, Sun XS#, Qin JM, Zhao QH, Liao WP, Long YS*. Experimental identification of microRNA targets on the 3' untranslated region of human FMR1 gene. J Neurosci Methods. 2010; 190(1):34-8. (IF=2.2)
[11]. Huang MQ, Zhang JG, Long YS*. Identification of novel cyclic nucleotide phosphodiesterase gene cDNAs in the cochlea of guinea pig (Cavia porcellus) through conserved homologous sequences. Mol Biotechnol. 2010; 44(1):66-70. (IF=2.4)
[12]. Shao JL#, Long YS#, Chen G, Xie J, Xu ZF. The reversed terminator of octopine synthase gene on the Agrobacterium Ti plasmid has? a weak promoter activity in prokaryotes. Mol Biol Rep. 2010; 37(5):2157-62. (IF=2.9)
(* Corresponding author, # Co-first author)

 

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地址:广州市海珠区昌岗东路250号(510120) 广州医学院第二附属医院何善衡脑科中心