Institute of Neuroscience Guangzhou Medical University

 

Prof. Weiping Liao

  • "Ambassador of Epilepsy" awarded by IBE and ILAE
  • The Associate Editor of SEIZURE-European Journal of Epilepsy
  • Vice President of China Association Against Epilepsy
  • Director of Institute of Neuroscience, GZMU & Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China

  Dr. Wei-Ping Liao is a Professor of Neurology at the Second Affiliated Hospital of Guangzhou Medical University in China. He is now a vice president of China Association Against Epilepsy (CAAE). He graduated from Hunan Medical University in 1983 and subsequently trained in Neurology until 1986. He obtained further training in Epileptology in the National Epilepsy Center of Japan between 1988-1989. Now, he directs the Institute of Neurosciences and Epilepsy Unit, which provides a range of services for people with neurological disorders and epilepsies. He is also the director of the Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, leads a team in basic studies on epilepsy. His research interests include genetics, surgical management and pathological basis of epilepsy. He has published many papers in recent years, in journals like EPILEPSIA, NEUROGENETIS, NEUROSCIENCES, etc. He also served as an editorial board member of Epilepsia, and reviewer for many journals. He is an active member of the Asian Epilepsy Academy (ASEPA). He has organized and participated in several epilepsy conferences and teaching courses in China, under the auspices of ASEPA and CAAE in recent years. He was awarded Ambassador for Epilepsy in 2011 for his contributions in this field.

EDUCATION:

  • M.D. and M.S., Hunan Medical University, Changsha, P.R. China, 1978-1986
  • Ph.D., Sun Yat-Sen University of Medical Sciences, Guangzhou, P. R. China, 1994-1997

EXPERIENCE:

  • 1991-present Institute of Neurosciences, Guangzhou Medical University, Professor (Associate Professor before 1997)
  • 1989-1991 Department of Neurology, the 1st Affiliated Hospital of Hunan Medical University, Visiting Doctor
  • 1988-1989 National Epilepsy Center of Japan, Visiting Scholar, studied under Dr. M Seino, the former vice president of International League Against Epilepsy
  • 1986-1988 Department of Neurology, the 1st Affiliated Hospital of Hunan Medical University, Resident Doctor

AWARDS:

  • Ambassador for Epilepsy awarded by ILAE and IBE, 2012
  • The Second Prize for Scientific Research awarded by Scientific and Technologic Committee of Guangdong Province, 2010
  • The Second Prize for Scientific Research awarded by the Ministry of Education of China, 2003
  • The Second Prize for Scientific Research awarded by Scientific and Technologic Committee of Guangdong Province, 1995
  • Sackler Award for Chinese Doctor of the Year (1994) awarded by Sackler Foundation (US) and the Ministry of Health of China (organized by China Medical Tribune)
  • Gowers¡¯ Prize awarded by British Branch of International League Against Epilepsy, 1990

SCIENTIFIC CAREER:

  • Engaged in epileptology since 1988, begun with the strict training in national epilepsy center of Japan, following Dr. M Seino, the former vice president of International League Against Epilepsy and the father of Asian epileptology.
  • Have done a lot of studies after being back in China, and contributed greatly to the development of epileptology in China. Elected as a vice president of China Association Against Epilepsy when it is founded in 2005.
  • Being nominated and accredited as the vice director and then director of the Institute of Neuroscience of Guangzhou Medical University since 1998 by Dr Nanshan Zhong.
  • Engaged in genetics of epilepsy and channelopathies in recent years, a lot of important works have been published since then. Headed this institute to become the Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China in 2008.

PUBLICATIONS

  1. Shi Y-W, Min F-L, Zhou D, Qin B, Wang J, Hu F-Y, Cheung Y-K, Zhou J-H, Hu X-S, Zhou J-Q, Zhou L-M, Zheng Z-z, Pan J, He N, Liu Z-S, Hou Y-Q, Lim K-S, Ou Y-m, Hui-Ping Khor A, Ng C-C, Mao B-J, Liu X-R, Li B-M, Kuan Y-Y, Yi Y-H, He X-l, Deng X-Y, Su T, Kwan P, Liao W-P*. HLA-A*24:02 as a common risk factor for antiepileptic drug¨Cinduced cutaneous adverse reactions. Neurology, 2017; DOI: 10.1212/wnl.0000000000004008.

  2. Wei F, Yan L-M, Su T, Na H, Lin Z-J, Wang J, Shi Y-W, Yi Y-H, Liao W-P*. Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy. Neuroscience Bulletin, 2017; DOI: 10.1007/s12264-017-0134-1.

  3. Wang J, Lin ZJ, Liu L, Xu HQ, Shi YW, Yi YH, He N, Liao WP*. Epilepsy-associated genes. Seizure. 2017 Jan;44:11-20. DOI: 10.1016/j.seizure.2016.11.030.

  4. Xiao-Rong Liu, Dan Huang, Jie Wang, Yi-Fan Wang, Hui Sun, Bin Tang, Wen Li, Jin-Xing Lai, Na He, Mei Wu, Tao Su, Heng Meng, Yi-Wu Shi, Bing-Mei Li, Bei-Sha Tang, Wei-Ping Liao*.Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene. Neurol Genet. 2016 Apr; 2(2): e66. DOI: 10.1212/NXG.0000000000000066

  5. Gao QW, Hua LD, Wang J, Fan CX, Deng WY, Li B, Bian WJ, Shao CX, He N, Zhou P, Liao WP*, Shi YW*. A Point Mutation in SCN1A 5' Genomic Region Decreases the Promoter Activity and Is Associated with Mild Epilepsy and Seizure Aggravation Induced by Antiepileptic Drug. Mol Neurobiol. 2016 Mar 11 DOI: 10.1007/s12035-016-9800-y

  6. Meng H, Xu HQ, Yu L, Lin GW, He N, Su T, Shi YW, Li B, Wang J, Liu XR, Tang B, Long YS, Yi YH, Liao WP*. The SCN1A mutation database: updating information and analysis of the relationships among genotype, functional alteration, and phenotype.Hum Mutat. 2015 Jun;36(6):573-80.

  7. Chen YJ, Shi YW, Xu HQ,Chen ML, Gao MM,Sun WW, Tang B, Zeng Y, Liao WP*. Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A. Molecular Neurobiology 2014 2015 Jun;51(3):1263-70.

  8. Zeng T1, Dong ZF, Liu SJ, Wan RP, Tang LJ, Liu T, Zhao QH, Shi YW, Yi YH, Liao WP, Long YS.A novel variant in the 3' UTR of human SCN1A gene from a patient with Dravet syndrome decreases mRNA stability mediated by GAPDH's binding.Hum Genet. 2014 Jun;133(6):801-11. doi: 10.1007/s00439-014-1422-8.

  9. Dong ZF, Tang LJ, Deng GF, Zeng T, Liu SJ, Wan RP, Liu T, Zhao QH, Yi YH, Liao WP, Long YS.Transcription of the Human Sodium Channel SCN1A Gene Is Repressed by a Scaffolding Protein RACK1.Mol Neurobiol. 2014 Jan 17.

  10. Liu T, Wan RP, Tang LJ, Liu SJ, Li HJ, Zhao QH, Liao WP, Sun XF, Yi YH, Long YS. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome.Mol Neurobiol. 2014 Jun 7.

  11. Wang JL, Mao X, Hu ZM, Li JD, Li N, Guo JF, Jiang H, Shen L, Li J, Shi YT, Xia K, Liu JY, Liao WP, Tang BS. Mutation analysis of PRRT2 in two Chinese BFIS families and nomenclature of PRRT2 related paroxysmal diseases. Neurosci Lett. 2013.

  12. Liu XR, Wu M, He N, Meng H, Wen L, Wang JL, Zhang MP, Li WB, Mao X, Qin JM, Li BM, Tang B, Deng YH, Shi YW, Su T, Yi YH, Tang BS, Liao WP*. Novel PRRT2 mutations in paroxysmal dyskinesia patients with variant inheritance and phenotypes. Genes Brain Behav. 2013 Mar;12(2):234-40.

  13. Lv YD, Min FL, Liao WP, He N, Zeng T, Ma DH, Shi YW. The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a northern Han Chinese population. BMC Neurol. 2013; 13: 75.

  14. Deng GF, Liu SJ, Sun XS, Sun WW, Zhao QH, Liao WP, Yi YH, Long YS. A conserved region in the 3' untranslated region of the human LIMK1 gene is critical for proper expression of LIMK1 at the post-transcriptional level. Neurosci Bull. 2013;29(3):348-54.

  15. He N, Min FL, Shi YW, Guo J, Liu XR, Li BM, Zhou JH, Ou YM, Liao JX, Liao WP*. Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: incidence, features, risk factors and relation to HLA-B alleles. Seizure 2012 Oct; 21(8):614-8.

  16. Shi YW, Min FL, Qin B, Zou X, Liu XR, Gao MM, Wang Q, Zhou JQ, Liao WP*.Association between HLA and Stevens-Johnson Syndrome Induced by Carbamazepine in Southern Han Chinese: Genetic Markers besides B*1502? Basic Clin Pharmacol Toxicol. 2012 Feb 20. doi: 10.1111/j.1742-7843.2012.00868.x.Link

  17. Shi YW, Yu MJ, Long YS, Qin B, He N, Meng H, Liu XR, Deng WY, Gao MM, Yi YH, Li BM, Liao WP*. Mosaic SCN1A mutations in familial partial epilepsy with antecedent febrile seizures. Genes Brain Behav. 2012 Mar;11(2):170-6. Link

  18. Liao WP*, Shi YW, Min FL.HLA-B*1502 screening and toxic effects of carbamazepine.N Engl J Med. 2011 Aug 18;365(7):672-3.

  19. Li BM, Liu XR, Yi YH, Deng YH, Su T, Zou X, Liao WP*.Autism in Dravet syndrome: prevalence, features, and relationship to the clinical characteristics of epilepsy and mental retardation.Epilepsy Behav. 2011 Jul;21(3):291-5.

  20. Long YS, Qin JM, Su T, Zhao QH, Yi YH, Liao WP.Human transcription factor genes involved in neuronal development tend to have high GC content and CpG elements in the proximal promoter region.J Genet Genomics. 2011 Apr 20;38(4):157-63.

  21. Shi YW, Min FL, Liu XR, Zan LX, Gao MM, Yu MJ, Liao WP*.Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population.Basic Clin Pharmacol Toxicol. 2011 Jul;109(1):42-6.

  22. Su T, Paradiso B, Long YS, Liao WP, Simonato M.Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection.Brain Res. 2011 Apr 18;1385:68-76.

  23. Deng GF, Qin JM, Sun XS, Kuang ZY, Su T, Zhao QH, Shi YW, Liu XR, Yu MJ, Yi YH, Liao WP, Long YS. Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation.J Mol Neurosci. 2011 Jun;44(2):115-21.

  24. Min FL, Shi YW, Liu XR, Liao WP.HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome.Epilepsy Behav. 2011 Feb;20(2):390-1.

  25. Long YS, Deng GF, Sun XS, Yi YH, Su T, Zhao QH, Liao WP*.Identification of the transcriptional promoters in the proximal regions of human microRNA genes.Mol Biol Rep. 2011 Aug;38(6):4153-7.

  26. Long YS, Huang MQ, Liao WP.Identification of novel cyclic nucleotide phosphodiesterase gene cDNAs in the brain of guinea pig.Neurosci Bull. 2010 Oct;26(5):365-70.

  27. Wang YL, Zeng ZY, Song XW, Hao ZF, Shi YW, Tang B, Chen SQ, Gao MM, Di W, Long YS, Yi YH, Liao WP.A novel CLN2/TPP1 mutation in a Chinese patient with late infantile neuronal ceroid lipofuscinosis.Neurogenetics. 2011 Feb;12(1):93-5.

  28. Yu MJ, Shi YW, Gao MM, Deng WY, Liu XR, Chen L, Long YS, Yi YH, Liao WP*.Milder phenotype with SCN1A truncation mutation other than SMEI.Seizure. 2010 Sep;19(7):443-5.

  29. Wei-Ping Liao*, Yi-Wu Shi, Yue-Sheng Long, Yang Zeng, Tian Li, Mei-Juan Yu, Tao Su, Ping Deng, Zhi-Gang Lei, Shu-Jun Xu, Wei-Yi Deng, Xiao-Rong Liu, Wei-Wen Sun, Yong-Hong Yi, Zao C. Xu ,Shumin Duan.Partial epilepsy with antecedent febrile seizures and seizure aggravation by antiepileptic drugs: associated with loss of function of Na1.1.Epilepsia 2010; 51(9):1669¨C1678.Link

  30. Yi YH, Sun XS, Qin JM, Zhao QH, Liao WP, Long YS*. Experimental identification of microRNA targets on the 3' untranslated region of human FMR1 gene. J Neurosci Methods. 2010;190(1): 34-38.

  31. Wei-Ping Liao. Comments on the ¡°Revised terminology and concepts for organization of the epilepsies: Report of the Commission on Classification and Terminology¡±. Article in ILAE website. Article link

  32. Yue-Sheng Long, Yi-Wu Shi, Wei-Ping Liao*. Conservation-based prediction of the transcription regulatory region of SCN1A. Prog Nat Sci 2009, 19(12):1675-1681

  33. Su T, Cong WD, Long YS, Luo AH, Sun WW, Deng WY, Liao WP*. Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. Neuroscience. 2008 Dec 2;157(3):566-76. Pubmed-link

  34. Long YS, Zhao QH, Su T, Cai YL, Zeng Y, Shi YW, Yi YH, Chang HH, Liao WP*. Identification of the promoter region and the 5'-untranslated exons of the human voltage-gated sodium channel Nav1.1 gene (SCN1A) and enhancement of gene expression by the 5'-untranslated exons. J Neurosci Res. 2008 Nov 15;86(15):3375-81. Pubmed-link

  35. Yue-Sheng Long, Qi-Hua Zhao, Tao Zeng, Wei-Wen Sun, Wei-Ping Liao*. Characterization of The Promoter Region and Upstream Regulation Region of Human and Mouse SCN3A Gene*. Prog Biochem Biophys 2009; 36(3):339-345 Fulltext-Link

  36. LF Qiu, TJ Lu, XL Hu, YH Yi, WP Liao, ZQ Xiong*. Limbic epileptogenesis in a mouse model of fragile X syndrome. Cereb Cortex 2008; Oct 1 Pubmed-link

  37. Yi YH, Guo WC, Sun WW, Su T, Lin H, Chen SQ, Deng WY, Zhou W, Liao WP*. Neuroprotection of lamotrigine on hypoxic-ischemic brain damage in neonatal rats: Relations to administration time and doses. Biologics 2008; 2(2):339-44. Fulltext-Link

  38. Wei ZX, Yi YH*, Sun WW, Wang R, Su T, Bai YJ, Liao WP. Expression changes of microtubule associated protein 1B in the brain of Fmr1 knockout mice. Neurosci Bull. 2007 Jul;23(4):203-8. Pubmed-link

  39. Su T, Luo AH, Cong WD, Sun WW, Deng WY, Zhao QH, Zhang ZH, Liao WP*. Immunohistochemical investigation of voltage-gated potassium channel-interacting protein 1 in normal rat brain and Pentylenettrazole-induced seizures. Neurosci Bull. 2006 Jul;22(4):195-203. Pubmed-link

  40. Liao WP*, Chen L, Yi YH, Sun WW, Gao MM, Su T, Yang SQ. Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. Epilepsia. 2005;46 Suppl 1:21-4. Pubmed-link

  41. Wei-Ping Liao*, Yi-Wu Shi, Bing Qin, Tian Li, Mei-Juan Yu, Yu-Hong Deng, Xiao-Rong Liu, Yong-Hong Yi, Lun-Jiao FU, Wi-Yi Deng, Bing-Mei Li, Tao Su, Yue-Sheng Long. Partial epilepsy with febrile seizure plus: A subtype of GEFS+ or SME? Neurology Asia 2007;12(Supplement 1):78¨C79 Fulltext-link

  42. Wei-Ping Liao*. Antiepileptic drug trials with greater attention to daily clinical practice and special epilepsy syndromes.Neurology asia 2007; 12(Supplement1):30¨C32 Fulltext-link

  43. Chang HH, Su T, Sun WW, Zhao QH, Qin B, Liao WP*. Changes of potassium channels Kv4.2, Kv4.3 and Kv channel interacting protein 1 in amygdala kindling epilepsy: experiment with rats. Zhonghua Yi Xue Za Zhi. 2006 Dec 19;86(47):3315-8. Pubmed-link

  44. Wei-Ping Liao*, Shao-Qing Yang, Yong-Hong Yi, et al. An open-label study of topiramate as add-on therapy for epilepsy using slow titration. Neurology Asia 2005, 10:99-104 Fulltext-link

  45. Liao W* (invited presentation). Genetic Testing for Non-Familial Epilepsies. Abstract book of the 7th Asian & Oceanian Epilepsy Congress. Xiamen, China; 2008:15.

  46. Liao W*, Yu M, Shi Y, et al. Partial Epilepsy with Febrile Seizures Plus: A Subtype of Nav1.1 Channelopathies. Abstract book of the 7th Asian & Oceanian Epilepsy Congress. Xiamen, China; 2008:30.

  47. Yi YH, Liao WP, Lu X. Simultaneous determination of tryptophan, 5-hydroxytryptophan, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, 4-hydroxy-3-methoxyphenylacetic acid and 3-methoxy-4-hydroxyphenylglycol in human cerebrospinal fluid. J Chromatogr B Biomed Appl. 1994 Nov 4;661(1):143-8. Pubmed-link

*, corresponding author