Institute Of Neuroscience Guangzhou Medical University (ION-GZMU)


The department of basic science possess 3600 square meters and ownes a series of advanced equipments, such as confocal microscopy, patch clamp system and denaturing high performance liquid chromatography etc. There are 2 postdoctorals, 3 doctors, several lab assistants and over 10 graduate students. 

At present, basic research mainly focused on epilepsy, pediatric neurology and synaptic plasticity. The leader of epilepsy group, Professor Wei-ping Liao, the director of the Institute, is the vice-president of China Association against Epilepsy. The group is developing methods for genetic diagnosis of epilepsy. A new mutation in SCN1A has been found recently and the functional studying showed it maybe related to seizure aggravation by AEDs.

There is a group studying the role of voltage-gated potassium ion channel and Kv interaction protein (KChIP) in pathogenesis of epilepsy. Fragile-X syndrome is a common heritable form of mental retardation resulting from the abnormality of FMRP.

Special characteristic for Chinese children with Fragile-X syndrome have been reported by the pediatric neurology group. The mechanism of abnormalities in dendritic spine developing and plasticity in Fragile-X syndrome is being studied by using FMR-1 knockout mouse. Researches about the effect of antagonist of mGluR-1 on the abnormal development of dendritic spine is ongoing now.


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